Human Aortic Adventitial Fibroblasts

Description

Human Aortic Adventitial Fibroblasts are primary fibroblasts isolated from the outermost layer of the human aorta and are well suited for cell culture aortic fibroblasts applications. These adherent, spindle-shaped cells are cryopreserved at early passage and retain their native morphology and function. Cells are isolated from healthy donor aortic tissue unless otherwise specified. As key structural components of the vascular adventitia, they contribute to extracellular matrix production and participate in vascular remodeling and inflammatory signaling . In pathological conditions such as atherosclerosis and aneurysm, they interact dynamically with immune cells and smooth muscle cells, influencing disease progression. These cells express fibroblast-specific markers such as vimentin and FSP-1, as verified by immunostaining or flow cytometry. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.