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Primary Cells

Human Aortic Endothelial Cells-Diabetic Type I

  • For research use only

Cat No.

ABC-TC3495
Product Type

Vascular Cells
Cell Type

Endothelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Aorta
Disease

Normal
Storage

Liquid Nitrogen

Human Aortic Endothelial Cells-Diabetic Type I ,Primary endothelial cells from diabetic type I donors; model for vascular biology and metabolic disease.

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  • Human Aortic Endothelial Cells-Diabetic Type I
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Home | Primary Cells | Human Primary Cells | Blood System Primary Cells | Human Aortic Endothelial Cells-Diabetic Type I

Description

Human Aortic Endothelial Cells-Diabetic Type I are primary cells isolated from the descending aorta (arch to the renal artery) of confirmed Type 1 diabetic human donors. Following primary culture, these cells are cryopreserved. These cells, as the key cellular component of the human aortic endothelium, exhibit characteristic cobblestone morphology. These cells regulate vascular tone and barrier integrity but exhibit hallmark diabetic hyperglycemia-induced dysfunction including impaired nitric oxide synthesis, elevated ROS production, and sustained RAGE/NF-κB-mediated inflammation. These cells have been identified as critical contributors to diabetic vasculopathy, including accelerated atherosclerosis, aortic calcification, hypertension, and microvascular complications like nephropathy and retinopathy. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

Human Aortic Endothelial Cells Type I Diabetes, HAoECs T1DM, Aortic Endothelial Cells Diabetic Type I, Human Aorta ECs T1DM, Diabetic Type I Aortic ECs
Species

Human
Cat.No

ABC-TC3495
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Aorta
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Vascular Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Aortic Endothelial Cells-Diabetic Type I serve as a pathophysiologically relevant in vitro model to study diabetic vasculopathy in conditions like accelerated atherosclerosis and microangiopathy. Their disease-specific responsiveness enables detailed study of RAGE/NF-κB signaling pathways, particularly in hyperglycemia-induced ICAM-1 upregulation and monocyte adhesion. Researchers can utilize this model to screen advanced glycation end-product (AGE) inhibitors, evaluate NO-boosting therapies targeting plaque progression and develop targeted interventions for diabetic plaque progression and microvascular complications affecting renal and retinal tissues. The cells serve as a crucial translational bridge between basic diabetic vascular research and therapeutic development.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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