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Species | Human |
Cat.No | ABC-TC4328 |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Primary Cells |
Size/Quantity | 1 vial |
Cell Type | Mononuclear Cell |
Shipping Info | Dry Ice |
Growth Conditions | 37 ℃, 5% CO2 |
Source Organ | Peripheral Blood |
Disease | Cervical Cancer |
Storage | Liquid Nitrogen |
Product Type | Diseased Human Peripheral Blood Mononuclear Cells |
Human Cervical Cancer Peripheral Blood Mononuclear Cells are derived from the peripheral blood of patients with cervical cancer and separated by density gradient centrifugation. Round or oval mononuclear cells; suspension growth; weak adhesion. They contain T cells, B cells, NK cells and monocytes. These cells are round or oval in shape. Upregulated immune checkpoint molecules like PD-1 and CTLA-4; altered Th1/Th2 ratio indicating immune dysregulationThey are involved in anti-tumor immune responses. Studies have shown that abnormal phenotypes such as upregulated PD-1/CTLA-4 expression and imbalanced Th1/Th2 ratios are often found in PBMCs of patients with cervical cancer.PBMCs are non-tumorigenic but reflect tumor-associated immune dysfunction. Involvement in anti-tumor immune response and immune escape mechanisms related to cervical cancer progression.
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Human Cervical Cancer Peripheral Blood Mononuclear Cells can be used to study immune mechanisms, such as analyzing the expression of T cell exhaustion markers (PD-1, CTLA-4, TIM-3), and then studying how the cervical cancer microenvironment inhibits immune responses. They can also be used to test the activation effects of new immune checkpoint inhibitors, CAR-T cell therapy or vaccines on PBMCs.