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Primary Cells

Human Cervical Cancer Peripheral Blood Mononuclear Cells

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Included Diagnoses: Squamous Cell Carcinoma (including all subtypes) and Adenocarcinoma (including all subtypes), Carcinoma of the cervix.
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Species

Human

Cat.No

ABC-TC4328

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Mononuclear Cell

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Peripheral Blood

Disease

Cervical Cancer

Storage

Liquid Nitrogen

Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Cervical Cancer Peripheral Blood Mononuclear Cells are derived from the peripheral blood of patients with cervical cancer and separated by density gradient centrifugation. Round or oval mononuclear cells; suspension growth; weak adhesion. They contain T cells, B cells, NK cells and monocytes. These cells are round or oval in shape. Upregulated immune checkpoint molecules like PD-1 and CTLA-4; altered Th1/Th2 ratio indicating immune dysregulationThey are involved in anti-tumor immune responses. Studies have shown that abnormal phenotypes such as upregulated PD-1/CTLA-4 expression and imbalanced Th1/Th2 ratios are often found in PBMCs of patients with cervical cancer.PBMCs are non-tumorigenic but reflect tumor-associated immune dysfunction. Involvement in anti-tumor immune response and immune escape mechanisms related to cervical cancer progression.

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Citation

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Application

  • Human Cervical Cancer Peripheral Blood Mononuclear Cells can be used to study immune mechanisms, such as analyzing the expression of T cell exhaustion markers (PD-1, CTLA-4, TIM-3), and then studying how the cervical cancer microenvironment inhibits immune responses. They can also be used to test the activation effects of new immune checkpoint inhibitors, CAR-T cell therapy or vaccines on PBMCs.

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