Human Cervical Cancer Peripheral Blood Mononuclear Cells

Description

Human Cervical Cancer Peripheral Blood Mononuclear Cells (PBMCs) are immune cells isolated from the peripheral blood of cervical cancer patients through density gradient centrifugation. These round/oval mononuclear cells (comprising T cells, B cells, NK cells, and monocytes) exhibit a characteristic suspension growth pattern with weak adhesion. They demonstrate tumor-associated immune dysfunction, marked by upregulated immune checkpoint molecules (PD-1, CTLA-4), Th1/Th2 ratio imbalance, and altered cytokine profiles (e.g., reduced IFN-γ, elevated IL-10). These PBMCs reflect systemic immune dysregulation in cervical cancer, contributing to both anti-tumor responses and immune escape mechanisms. Their gene expression profile shows elevated immune checkpoint genes (PDCD1, CTLA4), making them valuable for studying tumor-immune interactions and immunotherapy efficacy in cervical cancer progression. These PBMCs support comprehensive PBMC phenotyping in cervical cancer, enabling analysis of T cell subsets in cervical cancer, the B cell role in cervical cancer, cytokine expression in cervical cancer, detection of autoimmune markers in cervical cancer, and monitoring of cervical cancer progression.