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Primary Cells

Human Esophageal Epithelial Cells

  • For research use only

Cat No.

ABC-TC3612
Product Type

Esophageal Cells
Cell Type

Epithelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Esophagus
Disease

Normal
Storage

Liquid Nitrogen

Human Esophageal Epithelial Cells form a non-keratinized barrier, express CK14/CK4/filaggrin, and serve for acid injury, Barrett’s, and cancer modeling.

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  • Human Esophageal Epithelial Cells
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Esophageal Epithelial Cells

Description

Human Esophageal Epithelial Cells are derived from the human esophagus, a tubular organ made of mucosa, submucosa, muscle, and adventitia. These primary cells exhibit typical epithelial cobblestone morphology in culture and form stratified layers under air-liquid interface conditions. Functionally, they act as a critical barrier against mechanical and chemical damage. The epithelium has three layers: a proliferating basal cell compartment, a differentiating suprabasal compartment, and a superficial squamous layer. The cells retain functional tight junctions and barrier properties, with proper expression of esophageal-specific genes (ESRP1, SOX2) and differentiation markers (involucrin, filaggrin). They demonstrate physiological proliferation rates and respond appropriately to growth factors (EGF, KGF). These cells are used to study esophageal function, disease models (e.g., esophageal cancer, acid reflux, Barrett’s esophagus), and cellular responses to stress. These cultures provide a human reference for studies comparing the stratified squamous epithelium esophagus with models derived from mouse esophagus, supporting multi-species analyses of epithelial biology.

Product Code

HEEC
Species

Human
Cat.No

ABC-TC3612
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Esophagus
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Esophageal Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human esophageal epithelial cells can be used to investigate gene expression involved in the formation of adherens and tight junctions. Using human esophageal epithelial cells, it was found that the loss of E-cadherin enhanced migration and invasion. Moreover, EGFR overexpression induces epithelial hyperplasia and thickens epithelium. The expansion of the proliferating basal cells and impaired differentiation can be observed with the expression of inducible AKT in human esophageal epithelial cells. Esophageal squamous cell carcinoma (ESCC) is one of the most common and serious malignancies. Esophageal epithelial cell lines were used to identified potential biomarkers for ESCC, such as p53, Orai1, GPX3, REPS2, esophagin, proliferating cell nuclear antigen (PCNA), epithelial cell transforming sequence 2 (ECT2), etc.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • Can Human Esophageal Epithelial Cells be used immediately after thawing for flow cytometry without culturing, and is it possible to omit the medium kit and coating solution?

    While it may seem convenient to use the cells immediately after thawing, we recommend culturing the cells for at least one passage before performing flow cytometry. The freeze–thaw and shipping process may temporarily reduce cell viability, and analyzing them directly could affect the quality and accuracy of flow staining results.

  • What type of epithelial tissue lines the esophagus?

    The esophagus is lined by stratified squamous epithelium. This epithelial tissue provides protection against mechanical stress caused by swallowing and food passage while maintaining tissue integrity.

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High Viability
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To support a consistent result
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