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Primary Cells

Human Esophageal Epithelial Cells

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The human esophagus is lined by a non-keratinizing, moist stratified squamous epithelium whose apical cell membranes and intercellular junctional complexes combine to produce an effective permeability barrier against the influx of luminal content. In particular, the barrier created by these structures limits exposure of the surface cells' basolateral cell membranes and entire membrane of cells […]
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Product Code

HEEC

Species

Human

Cat.No

ABC-TC3612

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Epithelial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Esophagus

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Esophageal Cells

Description

Human esophageal epithelial cells are Human Esophageal Epithelial CellsHuman Esophageal Epithelial Cells are derived from the human esophagus, a tubular organ made of mucosa, submucosa, muscle, and adventitia. These stratified squamous epithelial cells form a critical barrier against mechanical and chemical damage. The epithelium has three layers: a proliferating basal cell compartment (expressing CK5 and CK14), a differentiating suprabasal compartment (expressing CK4 and CK17), and a superficial squamous layer (containing filaggrin and involucrin). Unlike murine epithelium, human esophageal epithelium is non-keratinized and retains nuclei, providing a unique barrier function. These cells are used to study esophageal function, disease models (e.g., esophageal cancer, acid reflux, Barrett’s esophagus), and cellular responses to stress. Cryopreserved at early passages to maintain differentiation capacity, they should avoid repeated freeze-thaw cycles.

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Citation

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Application

  • Human esophageal epithelial cells can be used to investigate gene expression involved in the formation of adherens and tight junctions and tight junctions. Using human esophageal epithelial cells, it was found that the loss of E-cadherin enhanced migration and invasion.. Moreover, EGFR overexpression induces epithelial hyperplasia and thickens epithelium. The expansion of the proliferating basal cells and impaired differentiation can be observed with the expression of inducible AKT in human esophageal epithelial cells. Otherwise, Esophageal squamous cell carcinoma (ESCC) is one of the most common and serious malignancies. Esophageal epithelial cell lines were used to identified potential biomarkers for ESCC, such as p53, Orai1, GPX3, REPS2, esophagin, proliferating cell nuclear antigen (PCNA), epithelial cell transforming sequence 2 (ECT2), etc.

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