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Primary Cells

Human Uterine Fibroblasts

  • For research use only

Cat No.

ABC-TC3618
Product Type

Female Reproductive Cells
Cell Type

Fibroblast
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Uterus
Disease

Normal
Storage

Liquid Nitrogen

Human Uterine Fibroblasts support studies on uterine tissue remodeling, fibrosis, and smooth muscle differentiation in gynecological research.

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  • Human Uterine Fibroblasts
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Home | Primary Cells | Human Primary Cells | Reproductive System Primary Cells | Human Uterine Fibroblasts

Description

Human Uterine Fibroblasts (HUF) are primary stromal cells isolated from the human uterine wall, typically the myometrium or endometrial stroma. These cells display spindle-shaped or stellate morphology with large, oval nuclei and transparent cytoplasm, characteristic of mesenchymal origin. HUF express high levels of vimentin, CD90 (Thy-1), and fibroblast activation protein (FAP), and are essential for maintaining the structural integrity of uterine tissue. Functionally, they contribute to extracellular matrix (ECM) remodeling, wound healing, and inflammatory responses. Dysregulation of their collagen synthesis and fibrotic activity has been linked to the development of uterine fibroids (leiomyomas) and other fibrotic disorders. These fibroblasts play a key role in hormone-responsive changes during the menstrual cycle and pregnancy. HUF are widely used in studies of reproductive biology, fibrosis, and tissue engineering. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.

Product Code

Human Uterine Fibroblasts, Uterus Fibroblasts Human, HUFs, Endometrial Stromal Fibroblasts, Myometrial Fibroblasts Human
Species

Human
Cat.No

ABC-TC3618
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Uterus
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Female Reproductive Cells
Quality Control

All cells test negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Uterine Fibroblasts (HUF) serve as a powerful tool for investigating uterine physiology and pathology. These cells are widely utilized to study extracellular matrix (ECM) remodeling mechanisms in conditions like uterine fibroids and endometriosis, where dysregulated collagen deposition drives fibrotic progression. Researchers use HUF to model hormonal interactions, particularly responses to estrogen and progesterone, which influence uterine tissue repair and inflammatory signaling. Their role in cell-cell communication also makes them valuable for co-culture systems with uterine smooth muscle or immune cells to mimic disease microenvironments.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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