+1 862-686-2696
Featured Products
Primary Cells
Immortalized Cell Lines
Stem Cells
Tumor Cell Lines
Transfected Stable Cell Lines
Exosomes
MicroRNA Agomir/Antagomir
Cell Culture Media, Kits & Reagents
Explore Products
Cell
Cell
MicroRNA
MicroRNA
Test and Analysis
Test and Analysis
Primary Cells

Human Hepatic Stellate Cells

  • For research use only

Cat No.

ABC-TC3645
Product Type

Hepatic Cells
Cell Type

Stellate Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Storage

Liquid Nitrogen

Human Hepatic Stellate Cells enable hepatic fibrosis modeling, extracellular matrix deposition analysis, and liver disease mechanism research in vitro.

Product Image
  • Human Hepatic Stellate Cells
Get a Quote
Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Hepatic Stellate Cells

Description

Human Hepatic Stellate Cells (hHSCs) are primary mesenchymal cells isolated from adult human liver tissue, representing a key component of hepatic non-parenchymal cell population. These perisinusoidal cells are characterized by their quiescent state under physiological conditions, characterized by cytoplasmic lipid droplets rich in vitamin A—storing over 80% of the body’s retinoid reserves. These cells are cryopreserved at early passages, ensuring high viability and minimal phenotypic drift. hHSCs play essential roles in maintaining extracellular matrix (ECM) homeostasis, regulating vitamin A metabolism, and modulating hepatic microcirculation through interactions with endothelial cells and hepatocytes. hHSCs express molecular markers including desmin, glial fibrillary acidic protein (GFAP), and collagen type I alpha 1 chain (COL1A1). Upon actvation, hHSCs upregulate α-smooth mucle actin (α-SMA) and connective tissue growth factor (CTGF), hallmark features of transdifferentiation associated with liver injury and fibrosis.

Species

Human
Cat.No

ABC-TC3645
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Stellate Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Hepatic Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Hepatic Stellate Cells (HHSC) are highly relevant for a broad range of in vitro applications, including hepatotoxicity assessment, drug screening, and metabolism profiling. Their unique physiological characteristic makes them invaluable for investigating liver function, hepatic microenvironment dynamics, and liver disease progression. Additionally, gaining a deeper understanding of the molecular mechanisms behind HHSC activation is critical for developing innovative therapeutic approaches in treating hepatic fibrosis, potentially reducing morbidity and mortality rates among patients suffering from chronic liver injuries.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • How many passages can Human Hepatic Stellate Cells typically undergo while maintaining their bioavailability and profile?

    Human Hepatic Stellate Cells are provided at passage 1 (P1) and can generally be expanded for 3–5 passages under AcceGen’s recommended culture conditions.

  • Online Inquiry
  • Product Reviews

Inquiring Human Hepatic Stellate Cells

We know how valuable your research is to you, but are you wondering what you can expect to pay for quick accurate results every time? Fill out a request in the form below and we’ll get back to you within 24 hours with a quote.
High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

Tags

Let's Advance Life Science Research Together

Contact Us
AcceGen Scroll Top Button