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Primary Cells

Human Intestinal Myofibroblasts

  • BSL

    1

  • 287
Human Intestinal Myofibroblasts (H-InMyoFib), cryopreserved at passage 2 with ≥500,000 cells per vial. H-InMyoFibs share phenotypic characteristics of both fibroblasts and smooth muscle cells but do not express smooth muscle markers.
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Intestinal Myofibroblasts
Product Code

H-InMyoFib
Species

Human
Cat.No

ABC-TC3880
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

MyoFibroblast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Intestine
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Intestinal Cells
Key Features

Backed by AcceGen advanced technology
Ship cryopreserved cells in dry ice
Quality-tested for accurate results

Description

Human Intestinal Myofibroblasts (HIMFs) are isolated from whole adult human intestines. They play a critical role in intestinal growth and development, repair, tumorigenesis, water and electrolyte transport, inflammation, and fibrosis. HIMFs can secrete the epidermal growth factor receptor ligand Amphiregulin (AREG) under the induction of TNF-α. In addition, in intestinal inflammation (such as Crohn’s disease), myofibroblasts are activated, accompanied by excessive deposition of extracellular matrix (ECM) components (including collagen and fibronectin), ultimately driving the process of intestinal fibrosis. This fibrotic response is mediated by TGF-β/Smad signaling and involves cross-talk with immune cells (particularly macrophages) and epithelial cells.

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Citation

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Application

  • Human Intestinal Myofibroblasts can be used to establish intestinal disease models, such as inflammatory bowel disease (IBD), intestinal fibrosis and colorectal cancer, which helps to further explore disease mechanisms and potential therapeutic targets. In addition, these cells can also be used as active ingredients for constructing in vitro intestinal models or biological scaffolds to simulate the intestinal microenvironment to study drug absorption, toxicity testing or host-microorganism interactions.

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