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Primary Cells

Human Mammary Epithelial Cells, Adult

  • BSL

    1

  • 218
The mammary gland consists of pseudostratified epithelia, with myoepithelila cells resting upon a basement membrane and apical glandular epithelial cells facing the lumen of the ducts and alveoli. Mammary epithelial cells undergo changes in growth, invasion, and differentiation throughout much of adulthood, and most strikingly during pregnancy, lactation, and involution. They proliferate and invade the […]
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Mammary Epithelial Cell, Adult
Product Code

HMEpiC
Species

Human
Cat.No

ABC-TC3691
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Mammary
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mammary Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Mammary Epithelial Cells, Adult reside within the ducts and lobules of the breast and play essential roles in maintaining mammary gland function, including milk synthesis and secretion during lactation .Morphologically, these cells display cuboidal to columnar epithelial shapes and form tight junctions, contributing to the epithelial barrier. HMECs undergo dynamic remodeling in response to hormonal changes during puberty, menstrual cycles, pregnancy, lactation, and involution (post-weaning).They grow adherently in vitro and express epithelial markers such as cytokeratins (CK7, CK8/18), E-cadherin, and epithelial cell adhesion molecule (EpCAM). The Key regulators include Estrogen, Prolactin and cytokines. Genetically, HMECs generally have a stable karyotype but can accumulate mutations during malignant transformation. This hormone-responsive plasticity makes the mammary epithelium particularly susceptible to oncogenic mutations, leading to breast cancer.

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Citation

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Application

  • Human Mammary Epithelial Cells, Adult can be used to study mammary gland physiological functions, hormone regulation mechanisms, and cell signaling pathways during mammary gland development. It can also be used to construct in vitro 3D culture models or organoids, simulate mammary gland microenvironment, and test drug sensitivity or toxicity.

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