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Primary Cells

Human Mantle Cell Lymphoma Bone Marrow Mononuclear Cells (Newly Diagnosed/Untreated)

  • For research use only

Cat No.

ABC-TC3885
Product Type

Bone Marrow Mononuclear Cells
Cell Type

Mononuclear Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bone Marrow
Disease

Mantle Cell Lymphoma
Storage

Liquid Nitrogen

Human Mantle Cell Lymphoma Bone Marrow Mononuclear Cells (Newly Diagnosed/Untreated) provide a critical resource for hematology and oncology.

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  • Human Mantle Cell Lymphoma Bone Marrow Mononuclear Cells (Newly Diagnosed/Untreated)
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Mantle Cell Lymphoma Bone Marrow Mononuclear Cells (Newly Diagnosed/Untreated)

Description

Human Mantle Cell Lymphoma Bone Marrow Mononuclear Cells (Newly Diagnosed/Untreated), derived from newly diagnosed and untreated patients, are malignant lymphoid cells associated with mantle cell lymphoma. These cells typically exhibit a relatively uniform population of small-to-medium-sized lymphoid cells. These malignant B cells evade normal cell cycle regulation, leading to uncontrolled proliferation and resistance to apoptosis. They infiltrate the bone marrow, lymph nodes, and frequently the gastrointestinal tract, causing systemic disease. Mantle cell lymphoma cells often harbor mutations in ATM, TP53, and NOTCH1, contributing to their aggressive clinical behavior. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.

Product Code

Human Mantle Cell Lymphoma Bone Marrow Mononuclear Cells (Newly Diagnosed/Untreated), MCL BM-MNCs (ND), Mantle Cell Lymphoma Bone Marrow MNCs Untreated, Newly Diagnosed MCL BM Mononuclear Cells
Species

Human
Cat.No

ABC-TC3885
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Bone Marrow
Disease

Mantle Cell Lymphoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Bone Marrow Mononuclear Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Mantle Cell Lymphoma Bone Marrow Mononuclear Cells (Newly Diagnosed/Untreated) serve as a valuable model for understanding mantle cell lymphoma pathogenesis, particularly the dysregulation of cell cycle control and the role of key mutations in disease progression. They are essential for preclinical drug testing, including evaluating novel targeted therapies such as BTK inhibitors, BCL-2 antagonists, and CD19-directed CAR-T cell immunotherapies.

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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