Human Pancreatic CAF-Stellate Cells are cancer-associated fibroblasts (CAFs) derived from pancreatic stellate cells (PSCs), playing a critical role in the tumor microenvironment (TME) of pancreatic cancer. Once activated, PSCs lose their lipid droplets and acquire a fibroblastic morphology, contributing to desmoplasia and ECM deposition. These cells are cultured as adherent monolayers with spindle-like morphology and exhibit moderate proliferative capacity. Typically used at low passage numbers (P3–P6) to preserve physiological relevance, they express key markers such as α-smooth muscle actin (α-SMA) and fibroblast activation protein (FAP), both indicative of their activated CAF phenotype. Functionally, they regulate immune evasion, fibrosis, and hypoxia in pancreatic tumors. Although they are non-tumorigenic, their presence enhances tumor progression. The cells are routinely tested and confirmed negative for mycoplasma and viral contaminants including HIV, HBV, HCV, and EBV.
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