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Primary Cells

Human Pancreatic CAF-Stellate Cells

  • For research use only

Cat No.

ABC-TC5543
Product Type

Human Primary Carcinoma Associated Fibroblasts
Cell Type

Stellate Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreas
Disease

Normal
Storage

Liquid Nitrogen

Support Human Pancreatic CAF-Stellate Cells to model desmoplasia, tumor–stroma crosstalk, and therapy resistance in advanced pancreatic cancer models.

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  • Human Pancreatic CAF-Stellate Cells
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Home | Primary Cells | Human Primary Cells | Endocrine System Primary Cells | Human Pancreatic CAF-Stellate Cells

Description

Human Pancreatic CAF-Stellate Cells are cancer-associated fibroblasts (CAFs) derived from pancreatic stellate cells (PSCs), playing a critical role in the tumor microenvironment (TME) of pancreatic cancer. Once activated, PSCs lose their lipid droplets and acquire a fibroblastic morphology, contributing to desmoplasia and ECM deposition. These cells exhibit a stellate morphology with elongated cytoplasmic processes and express characteristic markers such as α-SMA, vimentin, and fibroblast activation protein (FAP), indicative of their activated CAF phenotype. Functionally, they play a pivotal role in pancreatic cancer progression by remodeling the extracellular matrix, promoting tumor growth, and mediating immunosuppression through secretion of cytokines and growth factors. They are widely used to study tumor-stroma interactions, fibrotic responses, and drug resistance mechanisms in pancreatic cancer.

Species

Human
Cat.No

ABC-TC5543
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Stellate Cell
Growth Mode

Adherent
Shipping Info

Dry ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Pancreas
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Human Primary Carcinoma Associated Fibroblasts

Application

  • Human Pancreatic CAF-Stellate Cells are used extensively in cancer research to investigate stromal remodeling, cell-cell signaling, and chemoresistance in pancreatic tumors. They provide a vital in vitro model to test antifibrotic agents, study tumor microenvironment interactions, and develop novel therapeutic strategies targeting cancer-associated fibrosis and immune evasion.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are Human Pancreatic CAF-Stellate Cells?

    Human pancreatic CAF-stellate cells are cancer-associated fibroblasts (CAFs) derived from pancreatic tissue. They play a significant role in the tumor microenvironment by interacting with cancer cells, influencing tumor growth, progression, and metastasis.

  • What is the distinction between human pancreatic CAF-stellate cells and traditional stellate cells?

    Human pancreatic CAF-stellate cells are fibroblasts found in pancreatic cancer tissues, not traditional stellate cells involved in fibrosis. Stellate cells are a separate cell type primarily associated with fibrosis and are not specifically linked to cancerous conditions in the pancreas.

  • What is the primary function of pancreatic CAF-stellate cells in cancer?

    The primary function of pancreatic CAF-stellate cells in cancer is to remodel the extracellular matrix, promote tumor cell proliferation, facilitate immune evasion, and enhance angiogenesis, thereby supporting tumor growth and metastasis.

  • How to isolate pancreatic CAF-stellate cells from tumor tissues?

    Pancreatic CAF-stellate cells are typically isolated from pancreatic tumor tissues through enzymatic digestion followed by cell culture techniques that allow the fibroblasts to proliferate while other cell types are minimized.

  • What are the research applications of pancreatic CAF-stellate cells?

    Pancreatic CAF-stellate cells are used in research to study tumor-stroma interactions, investigate the mechanisms of fibrosis in the pancreas, develop anti-cancer therapies targeting the tumor microenvironment, and understand the role of CAFs in cancer resistance to treatments.

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