Human Pancreatic Stromal Cells

Description

Human Pancreatic Stromal Cells (HPSCs) are primary cells derived from normal human pancreatic tissue through a combination of enzymatic digestion and outgrowth techniques, ensuring high purity of stellate cell populations. These cells exhibit a characteristic star-like morphology with prominent cytoplasmic extensions and perinuclear vitamin A lipid droplets in their quiescent state. In their quiescent state, PSCs store vitamin A droplets and secrete extracellular matrix proteins like collagen and fibronectin; upon pancreatic injury or inflammation, they activate and highly express α smooth muscle actin (α SMA), driving fibrotic processes. PSCs typically express intermediate filament markers such as desmin and GFAP. These cells are cryopreserved at early passage. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.