Pancreatic fibroblasts are mesenchymal cells found in periacinar, perivascular and periductal regions of pancreas with an essential role in structural support and would healing. Increasing evidences have suggested that pancreas harbours a heterogenous population of fibroblasts with distinct functions and expression patterns. The potential of pancreatic associated fibroblasts to promote fibrosis and develop into fibroinflammatory stroma is commonly associated with pancreatic diseases such as pancreatic ductal adenocarcinoma (PDA). Why choose Human Pancreatic Fibroblasts from AcceGen?
Human Pancreatic Fibroblasts are cryopreserved at passage 1 immediately after purification and delivered in dry ice. Each vial contains > 5×10^5 cells in 1 ml volume. Human pancreatic fibroblasts are not detected with HIV-1, HBV, HCV and other pathogens. Cells are characterized to positively express desmin and GFAP by immunofluorescence. Cells are tested negative for von Willebrand Factor Expression/Factor VIII, cytokeratin 18, and alpha smooth muscle actin. Human pancreatic fibroblasts are guaranteed to further expand for 3-5 passages following AcceGen recommended cell culture protocols.
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For research use only
Human pancreatic fibroblasts provide an ideal model for studying the heterogeneity of pancreatic fibroblast populations, as wells as their potential role in pancreatic injury and pancreatic cancer. They can also be used to investigate the origin and molecular characteristics of pancreatic cancer-associated fibroblasts.
-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results
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