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Human Pancreatic Fibroblasts | ||||
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| Product Name | Human Pancreatic Fibroblasts | |||
| Price | Get Quote | |||
| Cat.No | ABC-TC5470 | Species | Human | |
| Size/Quantity | 1 vial | |||
| Shipping Info | Dry Ice | Storage | Liquid Nitrogen | |
| Description | Pancreatic fibroblasts are mesenchymal cells found in periacinar, perivascular and periductal regions of pancreas with an essential role in structural support and would healing. Increasing evidences have suggested that pancreas harbours a heterogenous population of fibroblasts with distinct functions and expression patterns. The potential of pancreatic associated fibroblasts to promote fibrosis and develop into fibroinflammatory stroma is commonly associated with pancreatic diseases such as pancreatic ductal adenocarcinoma (PDA). | |||
| Disease | Normal | |||
| Source Organ | Pancreas | |||
| Recommended Medium And Supplement | ABM-TM5470 Human Pancreatic Fibroblasts Medium Kit | |||
| Citation Guide | When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID). | |||
| Application | For research use only | |||
| Key Features | -Backed by AcceGen advanced technology | |||
| Growth Conditions | 37 ℃, 5% CO2 | |||
| Cell Type | Fibroblast | |||
| Growth Mode | Adherent | |||
| Questionsthree | How do pancreatic fibroblasts affect the tumor microenvironment? | |||
| Product Type | Pancreatic Cells | |||
| Product Image |  | |||
Frequently Asked Questions
What are Human Pancreatic Fibroblasts?
Human pancreatic fibroblasts are specialized cells located in the pancreas that provide structural support and produce extracellular matrix components. They play a crucial role in maintaining the tissue architecture and function of the pancreas.
What is the primary function of pancreatic fibroblasts?
The primary function of pancreatic fibroblasts is to synthesize and remodel the extracellular matrix, support pancreatic tissue structure, and facilitate tissue repair and regeneration. They also play a role in modulating inflammation and fibrosis.
How do pancreatic fibroblasts affect the tumor microenvironment?
In the tumor microenvironment, pancreatic fibroblasts (often referred to as cancer-associated fibroblasts, or CAFs) secrete growth factors, cytokines, and extracellular matrix components that support tumor cell survival, proliferation, and invasion. They also contribute to the development of a fibrotic stroma that can impede drug delivery.
What are the therapeutic uses of targeting pancreatic fibroblasts?
Therapeutic applications include developing drugs that target fibroblast activity to reduce fibrosis and improve pancreatic function in diseases like chronic pancreatitis. In pancreatic cancer, targeting fibroblasts and their interactions with cancer cells could enhance the effectiveness of cancer treatments and inhibit tumor progression.
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