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Human Parkinson’s Disease Peripheral Blood Mononuclear Cells

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Parkinson&#39,s disease (PD) is a long-term degenerative disorder of the central nervous system.&nbsp,The disorder commonly causes stiffness or slowing of movement, tremors is another common symptom.
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Parkinson’s Disease Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4347
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Parkinson’s Disease
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Parkinson’s Disease Peripheral Blood Mononuclear Cells are a group of immune cells derived from the peripheral blood of patients with Parkinson’s disease (PD), mainly including lymphocytes (T cells, B cells, NK cells) and monocytes. These cells are morphologically chaeacterized as round or oval mononuclear cells. PBMCs play a central role in immune regulation and participate in inflammatory responses, antigen presentation, and cytotoxicity. Studies have shown that PBMCs in patients with PD have mitochondrial dysfunction, enhanced oxidative stress, and abnormal aggregation of α-synuclein, and these changes may be associated with the neurodegenerative process of PD.

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Citation

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Application

  • Human Parkinson’s Disease Peripheral Blood Mononuclear Cells can be used to study the immune dysregulation mechanisms in neurodegenerative diseases, such as the release of inflammatory factors cytokines (e.g.,TNF-α), mitochondrial dysfunction, and abnormal metabolism of α-synuclein. These cells can also be used as a source of disease biomarkers to assist in the early diagnosis of PD and monitoring of disease progression by detecting specific gene expression (such as LRRK2) or epigenetic modifications.

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