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Human Peripheral Blood Mononuclear Cells (PBMCs)

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Human Peripheral Blood Mononuclear Cells are available as positive and negative controls for T-cell monitoring in ELISPOT, ELISA, cytokine bead array, tetramer/pentamer, and flow cytometry assays. A peripheral blood mononuclear cell is defined as any blood cell with a round nucleus. These blood cells are a critical component in the immune system to fight infection […]
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Peripheral Blood Mononuclear Cells
Product Code

PBMCs
Species

Human
Cat.No

ABC-TC3726
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Normal Human Peripheral Blood Mononuclear Cells
Key Features

-Backed by AcceGen advanced technology
-Ship cryopreserved cells in dry ice
-Quality-tested for accurate results

Description

Human Peripheral Blood Mononuclear Cells (PBMCs) are a heterogeneous population of immune cells derived from peripheral blood, primarily consisting of lymphocytes (T cells, B cells, and NK cells) and monocytes, with smaller proportions of dendritic cells and progenitor cells. Morphologically, PBMCs are typically as small and round in shape. Functionally, they play a pivotal role in orchestrating both adaptive and innate immune responses: T cells and B cells mediate antigen-specific immunity, NK cells carry out cytotoxic killing, while monocytes differentiate into macrophages or dendritic cells to regulate inflammation and antigen presentation. Dysregulation of these cells can lead to chronic inflammation, immune deficiency, or hyperactivation.

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Citation

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Application

  • Human Peripheral Blood Mononuclear Cells (PBMCs) can be used to analyze immune cell functions, such as T cell proliferation, cytokine secretion, and antibody production, making them useful for valuating vaccine efficacy or investigating the mechanisms of immunomodulatory drugs. These cells can also be used to detect virus-specific immune responses, study immune escape mechanisms in the tumor microenvironment, and develop immunotherapy strategies such as CAR-T cell therapy.

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