Human Placental Vascular Endothelial Cells

Description

Human Placental Vascular Endothelial Cells (HPEC) are primary cells isolated from the microvasculature of full-term human placenta, specifically the fetal-side chorionic villi. These cells exhibit a polygonal or cobblestone morphology and frow as adherent monolayers with distinct endothelial characteristics (1). Functionally, HPEC play critical roles in placental angiogenesis, vascular barrier maintenance, and maternofetal nutrient exchange. Dysregulation of HPEC is linked to preeclampsia and gestational diabetes. These cells are characterized by high expression of CD31, VE-cadherin, and von Willebrand factor (vWF)(2). HPEC demonstrate limited proliferative capacity, making them suitable for short-term in vitro culture.

Application

• Human Placental Vascular Endothelial Cells (HPECs) are essential in vitro model for studying human vascular biology. They are widely used to investigate the intricate transcriptional networks and signaling pathways involved in placental endothelial differentiation during function during early and late pregnancy. These cells provide valuable insights into the mechanisms of placental angiogenesis, vasculogenesis and the pathophysiology of placental vascular disorders. HPECs support translational research aimed at identifying therapeutic targets and biomarkers for pregnancy complications, contributing to advancements in maternal-fetal medicine and developmental biology.