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Primary Cells

Human Placental Vascular Endothelial Cells

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Human Primary Placental Microvascular Endothelial Cells from Cell Biologics are isolated from human placental tissue. Human Primary Placental Microvascular Endothelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based solution for 2 min and incubated in AcceGen's Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells […]
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Home | Primary Cells | Human Primary Cells | Reproductive System Primary Cells | Human Placental Microvascular Endothelial Cells
Species

Human
Cat.No

ABC-TC5468
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Placental Cells

Description

Human Placental Vascular Endothelial Cells
Human Placental Vascular Endothelial Cells (HPEC) are primary cells isolated from the microvasculature of full-term human placenta, specifically the fetal-side chorionic villi. These cells exhibit a polygonal or cobblestone morphology and frow as adherent monolayers with distinct endothelial characteristics (1). Functionally, HPEC play critical roles in placental angiogenesis, vascular barrier maintenance, and maternofetal nutrient exchange. Dysregulation of HPEC is linked to preeclampsia and gestational diabetes. These cells are characterized by high expression of CD31, VE-cadherin, and von Willebrand factor (vWF)(2). HPEC demonstrate limited proliferative capacity, making them suitable for short-term in vitro culture.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • Human Placental Vascular Endothelial Cells (HPECs) are essential in vitro model for studying human vascular biology. They are widely used to investigate the intricate transcriptional networks and signaling pathways involved in placental endothelial differentiation during function during early and late pregnancy. These cells provide valuable insights into the mechanisms of placental angiogenesis, vasculogenesis and the pathophysiology of placental vascular disorders. HPECs support translational research aimed at identifying therapeutic targets and biomarkers for pregnancy complications, contributing to advancements in maternal-fetal medicine and developmental biology.

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