Human Renal Epithelial Cells

Description

Human Renal Epithelial Cells, specifically the tubular subtype, are isolated from healthy adult kidney tissue, maintaining intact epithelial barrier function. These renal tubular epithelial cells exhibit polygonal or cuboidal morphology and an adherent growth pattern. They are cyropreserved at early passages to maintain high viability and functionality. These primary kidney epithelial cells express renal-specific markers including aquaporin-1 (AQP1), megalin, and zona occludens-1 (ZO-1), with proper polarization and microvilli formation. The cells demonstrate physiological transport activity (Na⁺ /K⁺ ATPase) and respond appropriately to hormonal regulation (vasopressin sensitivity). They exhibit balanced expression of renal development genes and maintain metabolic functions critical for nephron modeling. They are ideal for studies on renal disease models, drug toxicity screening, ischemic injury, and tissue regeneration.

Application

• These renal epithelial cells are essential for studying kidney physiology, including tubular transport mechanisms and electrolyte balance. Researchers utilize them to model acute kidney injury (cisplatin/nephrotoxin studies) and chronic kidney disease (fibrosis pathways). The cells support drug development applications for renal clearance prediction and nephrotoxicity screening. Additionally, they are valuable for investigating inherited renal disorders (polycystic kidney disease) and developing bioartificial kidney devices through their barrier and transport functionalities.