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Primary Cells

Human Renal Epithelial Cells

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Human Renal Epithelial Cells(Human kidney epithelial cells) are derived from whole kidneys that have been dissociated into single cells and purified in culture. Human kidney epithelial cells are from a single donor. These are highly purified epithelial cells as determined by specific epithelial cell markers. Human kidney epithelial cells enable researchers to study the development […]
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Species

Human

Cat.No

ABC-TC3782

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Epithelial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Kidney

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Renal Cells

Description

Human Renal Epithelial CellsHuman Renal Epithelial Cells are isolated from whole human kidneys of healthy donors. These cells are a type of primary epithelial cells, showing polygonal or cuboidal morphology and an adherent growth pattern. They are cyropreserved at early passages to maintain high viability and functionality. Human renal epithelial cells play a key role in kidney tissue morphogenesis and repair, notably responding to acute kidney injury (AKI) by rapid proliferation. They express epithelial markers such as cytokeratin 18 and 19. Their karyotype is human diploid (46,XX or 46,XY), indicating genomic stability. Tthey are ideal for studies on renal disease models, drug toxicity screening, ischemic injury, and tissue regeneration.

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Citation

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Application

  • Research on human renal epithelial cells is essential for bioartificial kidney engineering strategies. The polarization of human renal epithelium is originated from integrin-mediated cell-matrix adhesion, which responds to matrix stiffness, as shown by cellular mechanobiology studies. This suggests matrix stiffness could be used to regulate proliferative cells. In the heterogeneous epithelial cells, renal tubule epithelial cells express toll-like receptors (TLRs) and may respond to bacterial infection and ischemic stress via innate immunity.The role of TLRs in the kidney could be further investigated using human renal epithelial cells.

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