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Primary Cells

Human Renal Proximal Tubule Cells

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Normal Human Renal Epithelial Cells, when grown in LIRen Medium, provide an ideal low-serum culture model for the study of renal function, metabolism, nephrotoxicity or cancer research. Renal Proximal Tubule Epithelial Cells are cryopreserved as secondary cells to ensure the highest viability and plating efficiency. Our Renal Epithelial Cells are quality tested in LIRen Medium […]
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Home | Primary Cells | Human Primary Cells | Urinary System Primary Cells | Human Renal Proximal Tubule Cells
Species

Human
Cat.No

ABC-TC4248
Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Tubular Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Kidney
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Renal Cells
Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes

Description

Human Renal Proximal Tubule Cells (RPTCs) are primary epithelial cells isolated from the proximal convoluted segment of normal adult human kidneys. In vitro, RPTCs display characteristic epithelial features, such as a spread monolayer, and retain their functional properties under specific culture conditions. They form a polarized monolayer and play essential roles in reabsorbing glucose, amino acids, sodium, and bicarbonate, while secreting waste and xenobiotics. RPTCs express renal markers like γ-glutamyl transpeptidase, alkaline phosphatase, megalin, and transporters (OAT1, OCT2), important for nephrotoxicity studies. They are sensitive to toxins and ischemia, making them a crucial in vitro model for kidney function and disease research. These cells are cryopreserved at early passage.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • Due to their essential role in renal homeostasis, human renal proximal tubule cells provide a valuable tool for studying the biology and pathophysiology of renal tubular cells in vitro. They can used in studies including:

  • – HRPTCs repair mechanism after injury and their role in the progression of renal fibrosis.

  • – Intercellular talk between HRPTCs and other cells.

  • – High-throughput screening of drugs and toxicities.

  • – Role in renal diseases such as tubular necrosis, tubulointerstitial injury, nephrotoxicity, and renal cancer.

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