Human Retinal Endothelial Cells

Description

Human Retinal Endothelial Cells (HREC) are primary microvascular endothelial cells isolated from the inner retinal vasculature of healthy human donors. These adherent, cobblestone-like cells are preserved at early passage to preserve physiological function. HRECs express key endothelial markers including CD31 (PECAM-1), VE-cadherin, von Willebrand factor (vWF), and exhibit uptake of acetylated LDL and binding to Ulex europaeus agglutinin I—confirming their identity as vascular endothelial cells. They maintain tight junction proteins such as claudin-5 and occludin, which are crucial for inner blood-retinal barrier (iBRB) integrity. HRECs respond to VEGF, TNF-α, and hypoxia, making them a physiologically relevant model for retinal angiogenesis and vascular inflammation. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.