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Primary Cells

Human Retinal Pigment Epithelial Cells

  • For research use only

Cat No.

ABC-TC3791
Product Type

Ocular Cells
Cell Type

Epithelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Retina
Disease

Normal
Storage

Liquid Nitrogen

HRPE cells form pigmented monolayers, express RPE65/CRALBP, support retinal health, and are applied in AMD, RP, and Stargardt’s disease research.

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  • Human Retinal Pigment Epithelial Cells
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Retinal Pigment Epithelial Cells

Description

Human Retinal Pigment Epithelial Cells (HRPECs) are primary epithelial cells isolated from the retina of healthy human donors via collagenase digestion. They constitute the monolayer known as the retinal pigment epithelium (RPE)—a specialized component of the human pigment epithelium—that forms the pigmented layer of the eye critical for retinal homeostasis. As a standard in vitro model of the native RPE, HRPECs are indispensable for studying RPE functions. These cells form a monolayer of polygonal cells rich in pigment granules and exhibit microvillous projections that interact with photoreceptor outer segments, supporting phagocytic function. HRPECs maintain the outer blood-retina barrier and are essential for retinal homeostasis, nutrient transport, and visual cycle processing. Dysfunction of HRPE integrity is implicated in retinal degenerative diseases such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), and Stargardt’s disease. HRPECs express RPE65 and CRALBP, detected by immunocytochemistry or qPCR. Early passage HRPECs generally maintain a diploid karyotype and are not immortalized. They are tested negative for mycoplasma, bacteria, yeast, fungi, HIV-1, HIV-2, HTLV-I, and HTLV-II, ensuring biosafety compliance.

Product Code

HRPEpiC
Species

Human
Cat.No

ABC-TC3791
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Retina
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Ocular Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Retinal Pigment Epithelial Cells (HRPECs) serve as a critical model for advancing ocular research and developing novel therapies for retinal diseases. These specialized cells enable in-depth investigation of retinal development, homeostasis, and disease mechanisms underlying conditions like age-related macular degeneration (AMD), retinitis pigmentosa, diabetic retinopathy, and photoreceptor degeneration. By studying HRPEC gene expression, cellular interactions, and dysfunction, researchers can identify biomarkers, test drug efficacy, and design targeted treatments—including cell-based therapies and gene editing approaches. Their application bridges fundamental research and clinical translation, offering potential breakthroughs in early diagnosis, disease modeling, and regenerative medicine for vision impairment.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are Human Retinal Pigment Epithelial Cells?

    Human Retinal Pigment Epithelial (RPE) Cells are specialized pigmented cells located in the outermost layer of the retina. They provide essential support to photoreceptors, facilitate nutrient transport, and play a crucial role in visual function by absorbing stray light and maintaining retinal health.

  • What is the impact of dysfunction or degradation of Human Retinal Pigment Epithelial Cells?

    Dysfunction or degeneration of RPE cells is associated with several retinal diseases, including age-related macular degeneration (AMD) and retinitis pigmentosa. Loss of RPE cell function can lead to photoreceptor death, resulting in vision loss.

  • What are Human Retinal Pigment Epithelial Cells used for in research?

    These cells are extensively used in research focused on retinal diseases, photoreceptor biology, drug discovery, and tissue engineering. They are also integral to studies investigating the pathophysiology of AMD and the development of cell-based therapies for retinal degeneration.

  • Can Human Retinal Pigment Epithelial Cells be used in regenerative medicine?

    Yes, RPE cells are widely researched for use in regenerative therapies, especially for treating diseases like AMD. Transplantation of healthy RPE cells into the retina holds promise for restoring function in damaged retinal tissues and preventing further vision loss.

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