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Species | Human |
Cat.No | ABC-TC3794 |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Primary Cells |
Size/Quantity | 1 vial |
Cell Type | Sebocyte |
Shipping Info | Dry Ice |
Growth Conditions | 37 ℃, 5% CO2 |
Disease | Normal |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Skin Cells |
Human Sebocytes are primary cells isolated from normal human facial skin tissue, specifically derived from sebaceous glands. These cells exhibit epithelial morphology with adherent culture properties. Following primary culture, the cells are cryopreserved and typically maintain viability for limited passages in vitro. Functionally, sebocytes synthesize and secrete sebum, a lipid-rich mixture containing squalene, wax esters, and free fatty acids, which is critical for skin lubrication and barrier integrity. Their dysregulation is implicated in sebaceous gland-related pathologies such as acne vulgaris and seborrhoea, where excessive lipid production and inflammatory cytokine release (e.g., IL-8, TNF-α) contribute to disease pathogenesis. These cells express characteristic markers including Keratin-7 and MUC-1.
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Human sebocytes serve as a valuable in vitro model for fundamental research into the function and regulation of sebaceous cells, as well as a tool for exploring treatments of sebaceous gland-related conditions like acne and seborrhea. With their application in various studies, these cells shed light on sebaceous gland activity and its cellular-level control. Moreover, they enable the evaluation of agents’ inhibitory effects on sebocyte activity, contributing to a deeper understanding of these conditions and potential therapeutic strategies.