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| Species | Human |
| Cat.No | ABC-TC3794 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Sebocyte |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Skin Cells |
Cultured human sebocytes exhibit morphological changes during growth, transitioning from flat and elongated cells with round nuclei to larger, roundish cells with abundant cytoplasm and eccentric nuclei as secondary colonies develop. While maintaining key sebocytic traits, these cells undergo incomplete terminal differentiation in vitro. They synthetize fatty acids without bacterial involvement, express interleukin 1α, and respond to androgens in a location-dependent manner. Androgen-induced sebocyte proliferation is inhibited by spironolactone, and these cells demonstrate strong type 1 5α-reductase expression, metabolizing testosterone. Hormones like insulin, thyroid-stimulating hormone, and hydrocortisone stimulate proliferation, while retinoids inhibit proliferation, lipid synthesis, and differentiation, with isotretinoin as the most potent compound. Vitamin A proves crucial for sebocyte activity and differentiation, substitutable in part by synthetic retinoids.
Why choose Human Sebocytes from AcceGen?
Human Sebocytes from AcceGen are sourced from fully consented donors under IRB approval. These sebocytes are identified through Keratin-7 and MUC-1 staining as well as lipid accumulation assessment. With a purity exceeding 95%, the cultures are backed by optimized media for robust in vitro growth. These cells exhibit a consistent fibroblast morphology and boast high viability, guaranteeing reliability and suitability for various research applications.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
Human sebocytes serve as a valuable in vitro model for fundamental research into the function and regulation of sebaceous cells, as well as a tool for exploring treatments of sebaceous gland-related conditions like acne and seborrhea. With their application in various studies, these cells shed light on sebaceous gland activity and its cellular-level control. Moreover, they enable the evaluation of agents’ inhibitory effects on sebocyte activity, contributing to a deeper understanding of these conditions and potential therapeutic strategies.
