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Species | Human |
Cat.No | ABC-TC3814 |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Primary Cells |
Size/Quantity | 1 vial |
Cell Type | Epithelial |
Shipping Info | Dry Ice |
Growth Conditions | 37 ℃, 5% CO2 |
Source Organ | Intestine |
Disease | Normal |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Intestinal Cells |
Key Features | – Backed by AcceGen advanced technology |
Human Small Intestine Epithelial Cells are isolated from human small intestinal tissue. The cells are epithelial-like, polygonal, and grow in an adherent manner. These cells are located on the surface of the intestinal cavity and are the main site for food digestion and absorption. They play a key role in nutrient absorption, secretion, and motility. They are also the first line of defense for the body against pathogenic microorganisms and play a key role in the initial stage of mucosal immune response. Intestinal crypts and villi are structures within the intestinal epithelium that contain various specialized epithelial cell lineages, including absorptive enterocytes, enteroendocrine cells, goblet cells, and Paneth cells.They express epithelial markers such as cytokeratin 18 (CK18) and tight junction proteins like zonula occludens-1 (ZO-1), detectable by immunocytochemistry.
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Human Small Intestine Epithelial Cells can be used to study intestinal absorption and transport mechanisms. These cells can also be used to explore the pathogenesis of diseases such as inflammatory bowel disease (IBD) and leaky gut syndrome, and to test potential therapeutic strategies (such as tight junction regulators).
Human Small Intestine Epithelial Cells are cells that line the surface of the small intestine, responsible for absorbing nutrients, secreting enzymes, and forming a barrier against pathogens and toxins.
Human Small Intestine Epithelial Cells can typically be passaged 3-5 times before their characteristics and functionality begin to diminish. Researchers often aim to use cells within a limited number of passages to ensure reliable and reproducible results in experiments.
Human Small Intestine Epithelial Cells are involved in nutrient absorption (such as carbohydrates, proteins, and lipids), secretion of digestive enzymes and mucus, maintaining the intestinal barrier, and interacting with gut-associated lymphoid tissues to regulate immune responses.
Human Small Intestine Epithelial Cells are isolated from the small intestine, which includes the duodenum, jejunum, and ileum.