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Primary Cells

Human Small Intestine Epithelial Cells

  • For research use only

Cat No.

ABC-TC3814
Product Type

Intestinal Cells
Cell Type

Epithelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Intestine
Disease

Normal
Storage

Liquid Nitrogen

Human Small Intestine Epithelial Cells support digestive disease modeling, epithelial barrier studies, and gastrointestinal drug absorption research.

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  • Human Small Intestine Epithelial Cells
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Small Intestine Epithelial Cells

Description

Human Small Intestine Epithelial Cells are primary cells isolated from the intestinal mucosa, exhibiting characteristic epithelial morphology with polygonal shape and adherent growth. As the principal cellular component of the intestinal villi and crypts, they comprise specialized lineages including absorptive enterocytes (nutrient uptake), goblet cells (mucin secretion), enteroendocrine cells (hormone production), and Paneth cells (antimicrobial defense). These cells form a selective barrier through tight junctions (ZO-1, occludin) and adherens junctions (E-cadherin), while expressing epithelial markers like cytokeratin 18 (CK18). Functionally, they mediate digestion (brush border enzyme activity), nutrient absorption (SGLT1, PEPT1 transporters), and innate immunity (mucosal defense against pathogens via TLR signaling). Their polarized architecture and secretory activity (IgA transcytosis, defensin release) critically link intestinal homeostasis to systemic immune responses. These human intestinal cells, as representative gut epithelial cells, are essential for studying intestinal barrier function, nutrient transport, and host–microbe interactions in vitro.

Species

Human
Cat.No

ABC-TC3814
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Intestine
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Intestinal Cells
Key Features

– Backed by AcceGen advanced technology
– Cryopreserved for highest viability and plating efficiency
– Quality-tested for accurate results
– Expert teams to provide timely support and assist best experimental outcomes
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Small Intestine Epithelial Cells can be used to study intestinal absorption and transport mechanisms. These cells can also be used to explore the pathogenesis of diseases such as inflammatory bowel disease (IBD) and leaky gut syndrome, and to test potential therapeutic strategies (such as tight junction regulators).

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What are Human Small Intestine Epithelial Cells?

    Human Small Intestine Epithelial Cells are cells that line the surface of the small intestine, responsible for absorbing nutrients, secreting enzymes, and forming a barrier against pathogens and toxins.

  • How many times can Human Small Intestine Epithelial Cells be passaged in culture?

    Human Small Intestine Epithelial Cells can typically be passaged 3-5 times before their characteristics and functionality begin to diminish. Researchers often aim to use cells within a limited number of passages to ensure reliable and reproducible results in experiments.

  • What functions do Human Small Intestine Epithelial Cells perform in the small intestine?

    Human Small Intestine Epithelial Cells are involved in nutrient absorption (such as carbohydrates, proteins, and lipids), secretion of digestive enzymes and mucus, maintaining the intestinal barrier, and interacting with gut-associated lymphoid tissues to regulate immune responses.

  • Where are Human Small Intestine Epithelial Cells isolated from?

    Human Small Intestine Epithelial Cells are isolated from the small intestine, which includes the duodenum, jejunum, and ileum.

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