Human Synovial Microvascular Endothelial Cells

Description

Human Synovial Microvascular Endothelial Cells (hSyMECs) are isolated from the microvascular endothelium of human synovial tissue lining the joints. These cells are specialized endothelial cells that form the inner lining of synovial microvessels, playing a critical role in joint homeostasis and inflammation. In culture, hSyMECs exhibit a characteristic cobblestone morphology and form a tight, contact-inhibited monolayer. They demonstrate typical endothelial functions such as tubulogenesis and adhesion molecule expression. Phenotypically, they express endothelial markers including CD31 (PECAM-1), VE-cadherin, and von Willebrand factor (vWF). Karyotype analysis confirms genomic stability. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.