Human Venous Endothelial Cells

Description

Human Venous Endothelial Cells (HVECs) are primary cells derived from the venous endothelium, the innermost lining of veins. HVECs exhibit a typical cobblestone-like appearance when cultured in vitro, forming a confluent monolayer with polygonal shapes and tight cell-cell junctions. They regulate vascular tone, blood coagulation, immune responses, and barrier integrity. They produce vasoactive molecules such as nitric oxide (NO) and prostacyclin, which modulate vasodilation and inhibit platelet aggregation. HVECs express the endothelial marker CD31, which is commonly used for endothelial cell identification and reflects their role in vascular adhesion and endothelial function. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.