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| Product Code | HUP-T3; Hu-P-T3; HuPT3; HupT3; HUPT3 |
| Species | Human |
| Cat.No | ABC-TC497S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Pancreas |
| Storage | Liquid Nitrogen |
| Product Type | Human Pancreas Cancer Cell Lines |
HuP-T3 is a human pancreatic adenocarcinoma cell line derived from the ascites fluid of a 66-year-old Japanese male patient. This epithelial-like cell line exhibits adherent growth properties and demonstrates a doubling time of approximately 40–50 hours. Genomic profiling reveals critical mutations in KRAS (p.Gly12Arg), TP53 (p.Arg282Trp), and MSH6 (p.Lys1358fs*2. When xenografted into nude mice, HuP-T3 form poorly differentiated adenocarcinomas, confirming their tumorigenic potential. These characteristics position HuP-T3 as a valuable and physiologically relevant tool for investigating pancreatic cancer pathogenesis and therapeutic response mechanisms.
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The HuP-T3 cell line serves as a valuable model for pancreatic cancer research, particularly in studies focused on tumor invasion, migration, and metastasis.. It offers an effective platform to explore the molecular signaling pathways such as those involving KRAS and p53, which drive the aggressive behavior of pancreatic tumors. HuP-T3 cells are widely used in preclinical drug screening, enabling researchers to evaluate the efficacy of novel anticancer compounds and targeted therapies. Furthermore, its defined genetic alterations make it ideal for studying the cellular response to genotoxic stress, supporting the development of precision oncology strategies.
