Immortalized Human Intrahepatic Bile Duct Epithelial Cells

Description

Intrahepatic cholangiocytes are arranged into an intrahepatic biliary tree, forming a three-dimensional network of ducts of various diameters within the liver. Although they constitute only 3-5% of liver cells, they are responsible for producing up to 40% of the total bile produced daily. Numerous studies have indicated that intrahepatic cholangiocytes play a crucial role in maintaining, modulating, and expanding the structure of bile canaliculi by controlling hormone-regulated secretion and absorption.