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Immortalized Cell Lines

Immortalized Mouse Kupffer Cell Line (ImKC)

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Immortalised Mouse Kupffer Cells (ImKC) are isolated from male H-2Kb-tsA58 transgenic mice which expresses the thermolabile mutant tsA58 of SV40 40 large T antigen and were sorted through identifying the F4/80 marker. The Immortalised cells expresses p53 levels with increases telomerase activity and retains the some functional features compared to the primary cells. ImKC cells […]
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Home | Immortalized Cell Lines | Immortalized Mouse Kupffer Cell Line (ImKC)
Species

Mouse
Cat.No

ABI-TC192D
Quality Control

All cells are tested negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Immortalized Cell Lines
Size/Quantity

1 vial
Cell Type

Kupffer Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Biosafety Level

2
Storage

Liquid Nitrogen
Product Type

Immortalized Cell Line
Immortalization Method

Serial passaging and transduction with recombinant lentiviruses carrying SV40 Large T antigen.

Description

Immortalized Mouse Kupffer Cells (ImKC) SV40 infected Mouse Kupffer cells (mKCs) which are isolated from C57BL/6 mouse liver tissue. ImKC exhibit adherent growth with macrophage-like morphology. They show high telomerase activity, elevated wild-type p53 expression, and retain Kupffer cell functions like phagocytosis and immune surveillance. Besides F4/80, they express CD11b, CD14, and TLR4. These cells remain non-tumorigenic and non-metastatic in vivo. These cells are cryopreserved to maintain high viability and functionality.

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Citation

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Application

  • Immortalized Mouse Kupffer Cells (mKC) provide a powerful tool for investigating liver immune functions, macrophage biology, and hepatic disease mechanisms. These cells, with their authentic macrophage-like morphology and retained phagocytic and immune surveillance abilities, serve as an excellent model for studying Kupffer cell behavior in vitro. Their high telomerase activity and stable expression of immune markers like F4/80, CD11b, CD14, and TLR4 make them perfect for exploring inflammatory responses, innate immunity, and pathogen interactions. They offer a reliable system for drug screening, toxicology assays, and modeling liver-related diseases including fibrosis and hepatitis. Cryopreserved for high viability and functionality, these cells are an indispensable asset for researchers diving deep into liver immunology and macrophage-mediated pathophysiology.

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