Discover top-quality products tailored for scientific and medical research. Request a personalized quote today
to enhance your projects.
| Product Code | JIMT1; JIMT |
| Species | Human |
| Cat.No | ABC-TC504S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Breast |
| Disease | Breast Cancer |
| Storage | Liquid Nitrogen |
| Product Type | Human Breast Cancer Cell Lines |
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
JIMT-1 breast cancer cell line offers crucial roles in cancer research and drug development. It can generate xenograft tumors in mice models, allowing researchers to evaluate drug efficacy and inhibitor effectiveness both in vitro and in vivo. For instance, JIMT-1 cells have been extensively used to test HER-2-targeting drugs and small molecule tyrosine kinase inhibitors designed to block the HER-2 signaling pathway. Additionally, JIMT-1 cells can be utilized for genomic screening to identify key genes involved in cell proliferation and tumor growth. These applications make JIMT-1 a valuable tool for understanding breast cancer biology, investigating mechanisms of therapeutic resistance, and developing targeted therapies.
JIMT-1 cell line doubling time is 30-40h, and it is recommended to change medium every 2-3 days.
JIMT-1 cells overexpress HER-2 mRNA and are insensitive to drugs that inhibit HER-2 (such as trastuzumab). JIMT-1 cells have an amplified HER-2 oncogene, which showed no identifiable mutations in its coding sequence.
The cell line lacks expression of hormone receptors (estrogen receptors and progesterone receptors) and is phenotypically of epithelial progenitor cell origin.
The recommended cell density for JIMT-1 cells before passage is 1-2 × 10^5 cells/mL. We recommend to use a T-25 setup at a dilution of 1:5-1:10 (our cell count is approximately 1-2M/vial).
