KLN205/Cre Stable Cell Line

Description

KLN205/Cre Stable Cell Line is a genetically engineered murine lung squamous carcinoma model developed from the KLN205 parental cell line through stable integration of a constitutive Cre recombinase expression cassette. This specialized cell line maintains the characteristic epithelial morphology and tumorigenic properties of KLN205 cells while providing robust, nuclear-localized Cre recombinase activity for precise loxP-mediated genetic modifications. The stable Cre expression enables efficient recombination of floxed alleles, making this cell line particularly valuable for conditional gene knockout studies, lineage tracing experiments, and facilitating conditional gene knockout or activation of floxed oncogenes in lung cancer research. Applications include mechanistic studies of squamous cell carcinoma pathogenesis, evaluation of gene function in tumor progression, and development of genetically engineered cancer models. The cells have undergone rigorous quality control testing and are confirmed free of contamination from mycoplasma, fungi, yeast, and bacteria.