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KMM-1

  • BSL

    1

  • 438
Small round-cell morphology, part is multinucleate cell.
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Home | Tumor Cell Lines | Human Tumor Cell Lines | KMM-1
Product Code

KMM1
Species

Human
Cat.No

ABC-TC0517
Product Category Tumor Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte-like
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Disease

Multiple Myeloma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Human Myeloma Cell Lines

Description

Phase-contrast of KMM-1 human myeloma cells, exhibiting small, round-cell morphology with some multinucleate forms.
KMM-1 is a human plasma cell myeloma cell line that was originally isolated from the malignant subcutaneous tumor of a 62-year-old East Asian patient multiple myeloma. KMM-1 exhibits lymphoblast-like morphology. It displays a small round-cell shape with some multinucleate cells, growing in suspension with noticeable nucleoli and rough endoplasmic reticulum. KMM-1 demonstrated characteristic of plasma cell, it can secrets lambda chain into culture medium and lack expansion of Epstein-Barr virus nuclear antigen. Surface markers include E rosette (-), IgG Fc receptor (-), C3 receptor (-), S-Ig (+), TdT (-), and asialo-GM1 (-). KMM-1 are represent the later stage of B cell differentiation.

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Citation

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Application

  • KMM-1 cells find diverse applications in research, notably in investigating antioxidant, antiproliferative, and immunostimulatory effects. They serve as a valuable model to study cancer cell apoptosis induction by potential inhibitors. Additionally, they are integral in preclinical trials involving immunophenotypic and immunotypic evaluations. Furthermore, KMM-1 cells hold promise in evaluating potential therapeutic agents, including therapeutic small guide RNAs, against multiple myeloma, contributing significantly to advancing therapeutic strategies in this context.

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