For research use only
| Cat No. | ABC-TC0684 |
| Product Type | Human Skin Cancer Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Product Code | Mkl-1; MKL1 |
Explore MKL-1 for Merkel cell carcinoma modeling, viral integration analysis, and therapy response testing using a neuroendocrine skin cancer line.
MKL-1 is a human neuroendocrine carcinoma cell line derived from a metastatic lymph node of a 26-year-old male with Merkel cell carcinoma (MCC), a cutaneous neuroendocrine skin cancer. These suspension-growing cells form irregular aggregates, are hyperdiploid, and support continuous culture. MKL-1 harbors integrated Merkel cell polyomavirus (MCPyV) with approximately 3.5 viral genome copies per cell, expressing truncated large T-antigen and small T-antigen proteins critical for oncogenic transformation. The cells express neuroendocrine markers including cytokeratin 20, EMA, CAM5.2, neuron-specific enolase, and TTF-1, while lacking CK7, consistent with MCPyV-positive MCC phenotype. MKL-1 activates PI3K/AKT and NF-κB signaling pathways and is tumorigenic in nude mice. This line serves as a valuable model to study MCPyV-driven oncogenesis, viral antigen dependencies, signaling mechanisms, and therapeutic approaches in Merkel cell carcinoma.
| Product Code | Mkl-1; MKL1 |
| Species | Human |
| Cat.No | ABC-TC0684 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Growth Mode | Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Skin |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Skin Cancer Cell Lines |
MKL-1 cells, derived from metastatic Merkel cell carcinoma, are a key model for studying neuroendocrine tumor biology. They facilitate research on tumorigenesis, metastasis, drug responsiveness, and signaling pathways in skin cancers. Owing to their metastatic origin, MKL-1 cells are particularly valuable for investigating cancer dissemination and screening targeted therapies and chemotherapeutic agents.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
