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Tumor Cell Lines

MKL-1

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Human neuroendocrine skin carcinoma. MKL-1 was established from a nodal metastasis in a 26-year-old Caucasian male patient. MKL-1 cells contain a Merkel cell polyomavirus integrated into the genome.
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Product Code

Mkl-1; MKL1

Species

Human

Cat.No

ABC-TC0684

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Skin

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Skin Cancer Cell Lines

Description

MKL-1MKL-1 is a human skin neuroendocrine carcinoma cell line that was originally isolated from the lymph node of a 26-year-old patient with Merkel cell carcinoma. MKL-1 exhibits epithelial-like morphology and suspension culture properties. This cell line is aneuploid; it displays chromosomal counts within the hyperdiploid range. MKL-1 is tumorigenic and metastatic.

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Citation

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Application

  • Derived from metastatic Merkel cell carcinoma, MKL-1 cells are used to study neuroendocrine tumor biology. They enable the exploration of tumorigenesis, drug responsiveness, metastasis, and cellular signaling in skin cancers. Their origin from metastatic lesions makes them especially useful for investigating cancer spread and for screening targeted therapies and chemotherapy agents.

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