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| Product Code | MKN74; MKN 74 |
| Species | Human |
| Cat.No | ABC-TC0689 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Liver |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Gastric Cancer Cell Lines |
MKN-74 is a gastric cancer cell line derived from moderately differentiated tubular adenocarcinoma. They exhibit morphological characteristics associated with intestinal differentiation, including cell polarity and the presence of microvilli with core filaments, which is observed both in vitro and in nude mice models.
While MKN-74 cells typically have wild-type p53, some reports indicate the presence of a point mutation (I251L) in the p53 gene. Additionally, there is a loss of RUNX3 mRNA expression in these cells. MKN-74 cells express the synuclein γ (SNCG) gene, which has been shown to stimulate cancer cell proliferation and metastasis.
MKN-74 cells display an epithelial-like morphology and are adherent.
Why choose MKN-74 from AcceGen?
MKN-74 cells from AcceGen are a highly reliable and professional cell product that has undergone rigorous and standardized preparation conditions. They are provided in a sterile state, ensuring the absence of contamination from bacteria, fungi, and mycoplasma. These cells exhibit high viability, ensuring their robustness and suitability for various experimental applications. With their well-controlled preparation and quality assurance measures, MKN-74 cells offer researchers a reliable and convenient tool for conducting experiments and investigations in a wide range of biomedical studies.
When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
FOR RESEARCH USE ONLY
MKN-74 cells have versatile applications in gastric cancer research. Their use allows for investigating the impact of growth factors on cancer cell growth and apoptosis, shedding light on the molecular pathways involved and providing insights for novel therapeutic approaches. Additionally, MKN-74 cells serve as a valuable model to study the molecular pathways underlying the malignant potential and poor outcomes in gastric cancer, aiding in the identification of key targets for intervention and prognostic markers. Furthermore, these cells are instrumental in investigating drug resistance mechanisms in gastric cancer. By exposing MKN-74 cells to various anticancer drugs, researchers can unravel the resistance mechanisms and develop strategies to overcome them, potentially enhancing treatment outcomes for patients. Overall, MKN-74 cells play a crucial role in elucidating the complex biology of gastric cancer, facilitating the development of innovative therapies and approaches to combat this disease.
