MKN-74

Description

MKN-74 is a human gastric cancer cell line established from a moderately differentiated tubular adenocarcinoma of the stomach in a 37-year-old Japanese male. These epithelial-like cells exhibit adherent growth and display features of intestinal differentiation, including cell polarity and microvilli with core filaments, which are critical for the absorption and secretion functions in the intestinal epithelium, both in vitro and in nude mouse models. MKN – 74 expresses the synuclein γ (SNCG) gene. Studies have shown that overexpression of SNCG is associated with enhanced proliferation and metastatic capacity in gastric cancer cells, possibly by regulating cell cycle progression and extracellular matrix remodeling.

Application

• MKN-74 cells can be used to investigate how growth factors affect cancer cell growth and apoptosis, illuminating the molecular pathways involved and offering insights into novel therapeutic approaches. Additionally, MKN-74 serve as a valuable model for studying the molecular pathways underlying the malignant potential and poor prognosis in gastric cancer, aiding in the identification of key targets for intervention and prognostic markers. Furthermore, these cells are instrumental in investigating drug resistance mechanisms in gastric cancer. Exposing MKN-74 cells to various anticancer drugs allows researchers to unravel resistance mechanisms and develop strategies to overcome them, potentially improving treatment outcomes.