Monkey Kidney Glomerular Endothelial Cells

Description

Monkey Kidney Glomerular Endothelial Cells are primary endothelial cells isolated from the glomerular tissue of the kidney of the Cynomolgus Monkey. These cells exhibit a cobblestone-like morphology when confluent, with a flattened, polygonal shape and prominent nuclei, typical of vascular endothelial cells. They regulate selective filtration, maintain the glomerular filtration barrier (GFB), and modulate immune responses via cytokine secretion. Dysfunction of these cells is implicated in diabetic nephropathy, glomerulonephritis, and thrombotic microangiopathies, where endothelial injury leads to proteinuria and impaired filtration. Monkey Kidney Glomerular Endothelial Cells typically express endothelial-associated markers such as CD31, which can be detected by immunofluorescence staining or flow cytometry for cell identification. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.