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Primary Cells

Monkey Liver Sinusoidal Endothelial Cells

  • For research use only

Cat No.

ABC-TC3909
Product Type

Monkey Primary Cells
Cell Type

Endothelial
Species

Monkey
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Storage

Liquid Nitrogen

Monkey Liver Sinusoidal Endothelial Cells from AcceGen are isolated from tissue of Cynomolgus Monkey.

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  • Monkey Liver Sinusoidal Endothelial Cells
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Home | Primary Cells | Animal Primary Cells | Monkey primary cells | Monkey Liver Sinusoidal Endothelial Cells

Description

Monkey Liver Sinusoidal Endothelial Cells (LSECs) are primary endothelial cells isolated from the liver sinusoidal tissue of the Cynomolgus Monkey. LSECs exhibit a thin, fenestrated cytoplasm arranged in a sieve-like pattern, which facilitates the exchange of macromolecules between the blood and hepatocytes. They are crucial in maintaining liver homeostasis by clearing blood-borne waste (e.g., hyaluronan and endotoxins) via receptor-mediated endocytosis. Additionally, they modulate immune responses by presenting antigens and interacting with Kupffer cells and hepatic stellate cells. Key markers of LSECs include CD32b. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

Monkey Liver Sinusoidal Endothelial Cells, Monkey LSECs, Primate Hepatic Sinusoidal ECs, Liver Sinus ECs (Monkey)
Species

Monkey
Cat.No

ABC-TC3909
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Monkey Primary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Monkey Liver Sinusoidal Endothelial Cells are widely used in biomedical research due to their unique physiological and immunological properties. As NHP hepatic sinusoidal endothelium representing macaque liver endothelial cells, their primary applications include drug metabolism and toxicity studies, as they play a key role in filtering blood-borne substances, making them valuable for assessing hepatic clearance and nanoparticle drug delivery. Additionally, their fenestrated structure allows researchers to investigate sinusoidal capillarization, a hallmark of liver fibrosis and cirrhosis, aiding in the development of antifibrotic therapies.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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