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Primary Cells

Mouse Hepatic Sinusoidal Endothelial Cells

  • For research use only

Cat No.

ABC-TC3926
Product Type

Mouse Primary Cells
Cell Type

Endothelial
Species

Mouse
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Storage

Liquid Nitrogen

Mouse Hepatic Sinusoidal Endothelial Cells (MHSEC) are isolated from Swiss mice.

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  • Mouse Hepatic Sinusoidal Endothelial Cells
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Home | Primary Cells | Animal Primary Cells | Mouse Primary cells | Mouse Hepatic Sinusoidal Endothelial Cells

Description

Mouse Hepatic Sinusoidal Endothelial Cells (HSECs) are primary cells isolated from the hepatic sinusoids of healthy mice. As the specialized endothelial cells lining hepatic sinusoids, they exhibit a flattened, cobblestone-like morphology and adherent growth pattern. Functionally, HSECs mediate nutrient exchange and maintain immune tolerance through phagocytic activity and cytokine secretion. Dysregulation of these cells is associated with liver fibrosis, cirrhosis, and inflammatory liver diseases. The cells express endothelial markers CD31 and VE-cadherin. HSECs have limited proliferative capacity in vitro. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

MHSEC
Species

Mouse
Cat.No

ABC-TC3926
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Primary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Mouse Hepatic Sinusoidal Endothelial Cells (HSECs) serve as a relevant in vitro cellular model for investigating the underlying mechanisms of liver and vascular disorders, such as non-alcoholic fatty liver disease (NAFLD), cirrhosis, and portal hypertension. These cells are particularly valuable for modeling the hepatic sinusoid unique microenvironment, allowing investigation of endothelial-stellate cell interactions, leukocyte trafficking, and responses to metabolic stressors like hyperlipidemia or insulin resistance. By recapitulating key aspects of sinusoidal dysfunction, HSECs provide a better understanding of their physiological roles in liver homeostasis and their pathological alterations in disease, supporting discovery research and molecular target identification for liver-related vascular and degenerative disorders.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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