For research use only
| Cat No. | ABC-TC0706 |
| Product Type | Human Biphasic Mesothelioma Cell Lines |
| Cell Type | Fibroblast |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Disease | Biphasic Mesothelioma |
| Product Code | MSTO-211 H; MSTO211H; MSTO-211; 211H; MeSoTheliOma-211H |
Established from the pleural effusion of a 62-year-old Caucasian man with mesothelioma (malignant biphasic)
MSTO-211H is a human biphasic mesothelioma cell line derived from the pleural effusion of a 62-year-old Caucasian male diagnosed with malignant pleural mesothelioma of the lung. The cells display fibroblast morphology and adherent growth. MSTO-211H has a hypertriploid karyotype (modal chromosome number ~72, range from 70 to 80) with structural abnormalities characteristic of transformed lines. It expresses multiple tumor-associated markers including EGFR, neuron-specific enolase (NSE), and both α- and β-subunits of human chorionic gonadotropin (HCG), while lacking others such as bombesin and L-DOPA decarboxylase. The cell line exhibits moderate tumorigenicity in nude mice but does not display high metastatic potential. MSTO-211H has been widely used for oncogene profiling and therapeutic screening, with overexpression noted in C-myc, V-src, H-ras, and C-raf1. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, mycoplasma, fungi, yeast, and bacteria.
| Product Code | MSTO-211 H; MSTO211H; MSTO-211; 211H; MeSoTheliOma-211H |
| Species | Human |
| Cat.No | ABC-TC0706 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Fibroblast |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Lung |
| Disease | Biphasic Mesothelioma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Biphasic Mesothelioma Cell Lines |
MSTO-211H is a widely used in vitro and in vivo model for studying biphasic mesothelioma, a particularly aggressive subtype of pleural cancer. It is valuable for examining oncogenic signaling pathways, such as EGFR-mediated signaling, and for screening chemotherapy and targeted agents, including cisplatin-based regimens and kinase inhibitors. MSTO-211H is frequently employed in xenograft models to evaluate tumor growth and therapeutic responses. Its defined phenotype and stable growth characteristics make it ideal for translational studies, molecular profiling, and high-throughput drug screening relevant to asbestos-induced carcinogenesis.
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