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Primary Cells

Rat Aortic Fibroblasts

  • For research use only

Cat No.

ABC-TC4070
Product Type

Rat Primary Cells
Cell Type

Fibroblast
Species

Rat
Growth Conditions

37 ℃, 5% CO2
Source Organ

Aortic
Disease

Normal
Storage

Liquid Nitrogen

Rat Primary Aortic Fibroblasts from AcceGen are isolated from tissue of neonatal Sprague-Dawley Rats.

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  • Rat Aortic Fibroblasts
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Description

Rat Aortic Fibroblasts (RAoFb) are primary mesenchymal cells isolated from the aortic tissue of rats. These spindle-shaped, adherent fibroblasts robustly express extracellular matrix (ECM) proteins—such as collagen I, collagen III, fibronectin, and elastin—which contribute to aortic wall structure, stiffness, and remodeling in both developmental and pathological contexts. Their phenotype is characterized by expression of fibroblast-specific protein 1 (S100A4), confirming their activated, ECM-producing state. Functionally, they respond to vasoactive stimuli like angiotensin II and urotensin II with increased proliferation and ECM synthesis, and exhibit ECM remodeling dynamics under altered oxygen tension. Each lot undergoes rigorous screening and isolation procedures and is tested to ensure it is free from contamination by Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

Rat Aortic Fibroblasts, Rat Aorta Fibroblasts, Aortic Fibroblasts, RAFs
Species

Rat
Cat.No

ABC-TC4070
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Aortic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Rat Primary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • RAoFb are widely used to study vascular remodeling, ECM dynamics, and fibroblast activation in cardiovascular research. They serve as in vitro models for investigating the effects of vasoactive agents such as angiotensin II on collagen deposition and fibrotic signaling. RAoFb also support studies on aortic stiffening, hypertension-induced remodeling, and oxygen-sensitive fibroblast behavior, making them suitable for drug testing and fibrosis-targeted therapeutics.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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