Rat Brain Vascular Fibroblasts

Description

Rat Brain Vascular Fibroblasts are primary mesenchymal cells isolated from the cerebral microvasculature of rat brains under sterile conditions. These cells are obtained from the brain's perivascular region, where they contribute to the neurovascular unit by supporting the extracellular matrix (ECM) surrounding cerebral vessels. Morphologically, they exhibit a characteristic spindle-shaped, adherent phenotype and are cryopreserved at an early passage to preserve native phenotypic traits. Brain vascular fibroblasts play key roles in maintaining blood-brain barrier (BBB) integrity and are involved in the fibrotic remodeling observed in cerebrovascular disorders, including stroke and cerebral small vessel disease. Functionally, they express canonical mesenchymal marker vimentin. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.