Rat liver fibroblasts

Description

Rat Liver Fibroblasts are primary cells isolated from the hepatic interstitial connective tissue of healthy rats. These cells exhibit a characteristic elongated, spindle-shaped morphology and form adherent, contact-inhibited monolayers under standard culture conditions. Liver fibroblasts play a key role in maintaining the extracellular matrix (ECM) and are involved in tissue repair and fibrotic responses. They express fibroblast-specific markers including vimentin, fibronectin, and particularly under fibrogenic stimulation. Their high metabolic activity and responsiveness to cytokines like TGF-β and IL-6 make them ideal for fibrosis-related research. Cryopreserved at early passage, these cells retain excellent post-thaw viability and stable phenotypes. For optimal performance and consistency, repeated freeze-thaw cycles should be avoided. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.