Rat Lung Fibroblasts, Adult

Description

Rat Lung Fibroblasts, Adult are primary fibroblastic cells derived from the interstitial tissue of mature rat lungs. These cells display an elongated, spindle-like morphology and exhibit strong adherence to standard culture-treated surfaces, forming contact-inhibited monolayers during expansion. As key structural and regulatory cells within lung tissue, they actively participate in extracellular matrix (ECM) synthesis, remodeling, and wound healing processes. Adult lung fibroblasts express specific markers such as vimentin, fibronectin, and PDGFR-α, and may express α-smooth muscle actin (α-SMA) upon activation into a myofibroblast phenotype. Cryopreserved at early passage, these cells maintain high viability, consistent proliferation rates, and stable gene expression profiles. For optimal performance, repeated freeze-thaw cycles should be avoided. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.