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Immortalized Cell Lines

Retinal Müller Cell Line

  • For research use only

Cat No.

ABI-TC046D
Product Type

Immortalized Cell Line
Cell Type

Retinal Muller Cell
Species

Rat
Growth Conditions

37 ℃, 5% CO2
Source Organ

Eye
Disease

Normal
Storage

Liquid Nitrogen

Retinal Müller Cell Line serves as a reliable in vitro model for investigating cellular responses in retinal injury and diabetic retinopathy studies.

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  • Retinal Müller Cell Line
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Home | Immortalized Cell Lines | Retinal Müller Cell Line

Description

Retinal Müller Cell Line is a genetically engineered model originates from primary rat retinal Müller glia, designed to overcome the limitations of primary cell cultures while retaining essential physiological properties. These cells exhibit an immortalized phenotype through stable transformation with SV40 antigen, enabling proliferation without losing their characteristic radial glial morphology or marker expression. The cell line demonstrates consistent expression of Müller cell-specific proteins including glutamine synthetase (GS), cellular retinaldehyde-binding protein (CRALBP), and vimentin, along with functional glutamate uptake capabilities. Upregulation of glial fibrillary acidic protein (GFAP) occurs in response to retinal injury, inflammation, or stress. Compared to finite primary cultures, this immortalized line provides exceptional experimental consistency for studying chronic retinal pathologies, drug screening applications, and long-term mechanistic studies.

Species

Rat
Cat.No

ABI-TC046D
Product Category

Immortalized Cell Lines
Size/Quantity

1 vial
Cell Type

Retinal Muller Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Eye
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Immortalized Cell Line
Immortalization Method

transfecting primary Müller cell cultures
Morphology

Flat

Application

  • The Retinal Müller Cell Line offers a breakthrough in research, addressing the limitations of primary cultures. While primary Müller cells have been pivotal in cell biology, developmental, and electrophysiological studies, their short lifespan and susceptibility to non-neural cell contamination have imposed constraints. The establishment of a permanent Müller cell line opens doors to diverse investigations, encompassing the delineation of Müller cell-specific antigens, interactions with neurons and endothelial cells, profiling secreted growth factors and cytokines, and scrutiny of gene expression regulation. These advancements promise a deeper comprehension of Müller cell functions within the mammalian retina, heralding a new era of insightful research.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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