Rat Retinal Microvascular Endothelial Cells

Description

Rat retinal microvascular endothelial cells are primary microvascular endothelial cells isolated from the retina of Sprague-Dawley rats and cultured as adherent monolayers in endothelial growth medium under standard conditions. These cells exhibit typical endothelial morphology and express established endothelial markers including CD31 (PECAM-1) and von Willebrand factor (vWF), which are widely used to confirm endothelial identity in rodent vascular cells. They are viable for limited expansion in vitro and retain key microvascular behaviors that make them useful models for studying retinal angiogenesis, barrier integrity, and microvascular dysfunction relevant to diseases like diabetic retinopathy. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.