For research use only
| Cat No. | ABC-TC444S |
| Product Type | Human Melanoma Cell Lines |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
92.1 uveal melanoma cells express gp100, Melan-A, tyrosinase, form metastatic xenografts, and are used for 3D spheroid and drug screening models.
The 92. 1 cell line is a human uveal melanoma (UM) model derived from the primary tumor of a 76-year-old female patient with choroidal melanoma. UM is a rare but aggressive intraocular malignancy with high metastatic propensity, particularly to the liver. This cell line exhibits epithelial morphology and adherent culture properties. These cells retain key genetic hallmarks of the disease, including GNAQ/GNA11 mutations (present in ~90% of UM cases) and frequent BAP1 loss, associated with poor prognosis. 92. 1 cells express melanoma-associated antigens such as gp100, Melan-A/MART-1, and tyrosinase. This cell line is tumorigenic and metastatic, effectively forming subcutaneous xenografts in immunocompromised mice, with gene expression profiles indicating activation of MAPK/YAP signaling pathways. It also demonstrates invasive potential in transwell assays. It has been widely utilized to establish 3D spheroids and patient-derived xenograft models for drug screening.
| Species | Human |
| Cat.No | ABC-TC444S |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Biosafety Level | 2 |
| Storage | Liquid Nitrogen |
| Product Type | Human Melanoma Cell Lines |
The 92.1 cell line is a valuable model for studying uveal melanoma, providing insights into its molecular characteristics, progression, and metastasis. It is widely used to investigate tumor suppressor functions in uveal melanoma. Additionally, 92.1 cells support anti-proliferation assays with anticancer drugs, helping evaluate potential treatments. Their ability to form 3D spheroids enhances drug screening by offering more physiologically relevant conditions. Furthermore, these cells are instrumental in establishing xenograft models for human uveal melanoma, facilitating the screening of large compound libraries in drug discovery efforts.
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