92.1

Description

The 92.1 cell line is a human uveal melanoma model derived from the primary tumor of a 76-year-old female patient with choroidal melanoma. This cell line exhibits epithelial morphology and adherent culture properties. 92.1 cells express melanoma-associated antigens such as gp100, Melan-A/MART-1, and tyrosinase. This cell line is tumorigenic and metastatic, effectively forming subcutaneous xenografts in immunocompromised mice and demonstrating invasive potential in transwell assays. It has been widely utilized to establish 3D spheroids and patient-derived xenograft models for drug screening.

Application

• The 92.1 cell line holds significant applications in various fields of research. It serves as an invaluable tool for studying uveal melanoma and its molecular characteristics, aiding in the understanding of its progression and metastasis. Moreover, it plays a crucial role in investigating tumor suppressors in uveal melanoma. The cell line is also utilized as a model for anti-proliferation assays with anticancer drugs, enabling researchers to assess potential treatment options. Additionally, 92.1 cells are employed in forming three-dimensional (3D) spheroids for drug screening, allowing for more accurate and relevant evaluations. Furthermore, they are instrumental in establishing xenograft models of human uveal melanoma, proving to be effective in screening large compound libraries during drug discovery studies.