B6129SF2/J Mouse Kidney Epithelial Cells

Description

B6129SF2/J Mouse Kidney Epithelial Cells are primary cells isolated from the renal cortex of B6129SF2/J hybrid mice, a strain derived from C57BL/6J and 129S1/SvImJ parental lines. These cells exhibit a cobblestone-like epithelial morphology and are crucial for B6129SF2/J epithelial tissue research, particularly in studies of renal tubular function and injury. These cells exhibit limited proliferative capacity and should be used at early passages. They retain native epithelial characteristics, including the expression of E-cadherin and cytokeratins, and participate in ion transport, barrier maintenance, and response to inflammation. Studies indicate their involvement in renal pathophysiology, such as mitochondrial dysfunction in chronic kidney disease (CKD) and fibrosis. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.