B6129SF2/J Mouse Kidney Fibroblasts

Description

B6129SF2/J Mouse Kidney Fibroblasts are primary cells isolated from the kidney interstitial tissue of B6129SF2/J mice and are suitable for studies of B6129SF2/J kidney fibroblast gene expression under physiological and profibrotic conditions. These fibroblasts exhibit a typical spindle-shaped morphology and adherent growth properties. They play a crucial role in extracellular matrix production, tissue remodeling, and fibrogenesis during renal injury. In vitro, they express mesenchymal markers such as vimentin and α-SMA under profibrotic stimulation. Expression of vimentin and α-SMA is confirmed by immunocytochemistry under profibrotic conditions. These cells provide a biologically relevant model for exploring kidney fibrosis and chronic renal disease. The cells are cryopreserved at early passage, and exhibit limited proliferation capacity. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.