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Primary Cells

B6129SF2/J Mouse Liver Fibroblasts

  • For research use only

Cat No.

ABC-TC3047
Product Type

Mouse Primary Cells
Cell Type

Fibroblast
Species

B6129SF2/J Mouse
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Storage

Liquid Nitrogen

Mouse liver fibroblasts are isolated from tissue of pathogen-free laboratory mice.

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  • B6129SF2/J Mouse Liver Fibroblasts
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Home | Primary Cells | Animal Primary Cells | Mouse Primary cells | B6129SF2/J Mouse Liver Fibroblasts

Description

B6129SF2/J Mouse Liver Fibroblasts are primary cells isolated from the liver tissue of B6129SF2/J mice and provide a relevant model for studying b6129sf2 j fibroblast cell interaction within the hepatic microenvironment. They play a pivotal role in extracellular matrix (ECM) deposition during liver injury. They are implicated in hepatic fibrogenesis, particularly in response to toxins like carbon tetrachloride (CCl₄) or bile duct ligation, where they transition into myofibroblasts and contribute to collagen accumulation. These fibroblasts exhibit typical spindle-shaped morphology and adherent growth in vitro. Expression of α-SMA is confirmed by immunocytochemistry under fibrogenic stimulation. Studies confirm their involvement in cholestatic liver disease, with portal fibroblasts driving fibrosis via α-smooth muscle actin (α-SMA) expression. In vitro, these cells display limited proliferative capacity. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.

Product Code

B6129SF2/J Mouse Liver Fibroblasts, B6129SF2J liver fibroblasts, Mouse liver fibroblasts B6129SF2/J
Species

B6129SF2/J Mouse
Cat.No

ABC-TC3047
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Liver
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Mouse Primary Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • B6129SF2/J Mouse Liver Fibroblasts serve as a critical in vitro model for investigating liver fibrogenesis. They enable mechanistic studies on ECM dysregulation in toxin-induced fibrosis or cholestatic injury. Researchers utilize these cells to screen anti-fibrotic drugs targeting pathways like TGF-β1 or PDGF signaling. These cells demonstrate robust myofibroblast activation and collagen synthesis upon profibrotic stimuli, making them invaluable for therapeutic target discovery and fibrosis pathway elucidation. For instance, their role in epithelial-mesenchymal transition (EMT) provides insights into fibrosis progression in non-alcoholic fatty liver disease (NAFLD) models.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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