BALB/c Mouse Cardiac Fibroblasts

Description

BALB/c Mouse Cardiac Fibroblasts are primary cells isolated from the ventricular tissue of BALB/c mouse hearts. These spindle-shaped fibroblasts are critical for maintaining cardiac extracellular matrix (ECM) integrity and responding to myocardial injury. They are known for their ability to produce ECM proteins, including collagen I and III, and secrete paracrine factors that influence cardiomyocyte survival and vascular remodeling. Following isolation, the cells are cryopreserved at early passage to preserve their native phenotype. Studies show that cardiac fibroblasts actively contribute to the progression of fibrosis and heart failure by differentiating into myofibroblasts and expressing α-SMA under pathological stimuli. They participate in reactive oxygen species (ROS) signaling and inflammatory cytokine secretion, highlighting cardiac fibroblast contribution to cardiac pathology. These cells are non-immortalized, exhibit limited proliferation in vitro. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.