BALB/c Mouse Coronary Artery Endothelial Cells

Description

BALB/c Mouse Coronary Artery Endothelial Cells (MCAECs) are isolated from the coronary arteries of BALB/c mouse hearts. These cells line the interior surface of coronary vessels and play a crucial role in maintaining vascular tone, hemostasis, and barrier function. Morphologically, they appear cobblestone-like under culture conditions and exhibit strong expression of endothelial markers such as CD31 and VE-cadherin. Coronary endothelial cells are also involved in the regulation of leukocyte trafficking and angiogenesis. Research has shown that endothelial dysfunction is an early contributor to the pathogenesis of coronary artery disease and heart failure, often driven by oxidative stress and inflammatory signaling. These primary cells are cryopreserved at low passage to retain their physiological characteristics. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from Mycoplasma, Fungi, Yeast, and Bacteria.