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| Product Code | BEWO; Be Wo; Be-Wo |
| Species | Human |
| Cat.No | ABL-TC0104 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Placenta |
| Disease | Choriocarcinoma |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Uterine Cancer Cell Lines |
BeWo is a human choriocarcinoma cell line originally isolated from brain metastasis tissue of a male fetal placental tumor. The cells exhibit an epithelial-like morphology and grow as monolayer under adherent conditions, with a doubling time of approximately 30 hours. Characterized by a hypotetraploid stemline karyotype, with a modal chromosome number of 86, and a range of 71-178 chromosomes. BeWo cells express key trophoblast-specific markers, including human chorionic gonadotropin (hCG), placental lactogen, and various estrogen isoforms. They also displays tumorigenic potential and are permissive to poliovirus type 3 and vesicular stomatitis virus. Its unique capacity for syncytialization makes it particularly valuable for modeling placental barrier functions and hormonal regulation.
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BeWo cells are a widely used in vitro model for studying human placental development, particularly the syncytialization of trophoblast, a critical yet poorly understood process to investigate. Their abiity to undergo cell-cell fusion enables detailed exploration of placental villous trophoblast differentiation, hormonal regulation, and barrier function formation during early pregnancy. BeWo cells are instrumental in studying the molecular mechanisms behind placental hormone secretion, nutrient transport, and virus-host interactions, and are often used to evaluate the toxicological and pharmacokinetic effects of compounds crossing the placental barrier.
