Bovine Skeletal Muscle Fibroblasts

Description

Bovine Skeletal Muscle Fibroblasts (BSMFs) are primary interstitial fibroblasts isolated from cattle skeletal muscle. They play a central role in extracellular matrix (ECM) production—including type I and III collagen, fibronectin and proteoglycans—and are essential for muscle integrity and fibrosis regulation. In vitro, BSMFs maintain fibroblast-specific gene expression (e.g., VIM, FSP1) through multiple passages and after cryopreservation. They respond dynamically to TGF‑β1 and myostatin signaling, undergoing myofibroblast transformation with elevated α‑SMA and matrix remodeling capacity. These traits make BSMFs valuable for studies on muscle repair, fibrosis, cultivated meat scaffolds, and tissue-engineering platforms.