For research use only
| Cat No. | ABC-TC0097 |
| Product Type | Human Uterine Cancer Cell Lines |
| Cell Type | Epithelial |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Cervix |
| Disease | Cervical Cancer |
| Product Code | C-4II; C4 II; C4II |
C-4 II cervical carcinoma cells harbor integrated HPV-18 DNA and RNA, display hypodiploid karyotype, tumorigenic with epithelial monolayers.
C-4 II is a human cervical carcinoma cell line established from a 41-year-old Caucasian female. These epithelial-derived cells grow in adherent monolayers and form distinct hemicystic structures, characteristic of transporting epithelia. They exhibit contact inhibition, often lead to cell separation and exfoliation under high-density conditions. Despite long-term in vitro culture, C-4 II cells retain features of basal epithelial differentiation and express glucose-6-phosphate dehydrogenase (G6PD) type B. Cytogenetic analysis reveals a hypodiploid karyotype with multiple chromosomal abnormalities, consistent with genomic instability. Importantly, C-4 II cells contain integrated human papillomavirus type 18 (HPV-18) DNA and actively transcribe viral RNA, implicating HPV-driven oncogenesis. The cell line is tumorigenic in vivo, forming poorly differentiated squamous cell carcinomas upon subcutaneous injection into immunodeficient (nude) mice.
| Product Code | C-4II; C4 II; C4II |
| Species | Human |
| Cat.No | ABC-TC0097 |
| Product Category | Tumor Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Epithelial |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Cervix |
| Disease | Cervical Cancer |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Human Uterine Cancer Cell Lines |
The C-4 II cell line is widely used in diverse research fields. In 3D culture, it models cellular behavior and tissue architecture in physiologically relevant environments. In cancer research, C-4 II cells aid in studying cervical carcinoma progression and therapeutic target identification. Their interaction with HPV-18 offers a valuable system for investigating viral-host dynamics, antiviral strategies, and HPV pathogenesis, supporting advances in sexually transmitted disease prevention and treatment.
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