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Tumor Cell Lines

C-4 II

  • BSL

    1

  • 179
Human Caucasian cervical carcinoma. From a cervical carcinoma of a 41 year old Caucasian female.
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Product Code

C-4II; C4 II; C4II

Species

Human

Cat.No

ABC-TC0097

Product Category Tumor Cell Lines
Size/Quantity

1 vial

Cell Type

Epithelial

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Cervix

Disease

Cervical Cancer

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Human Uterine Cancer Cell Lines

Description

C-4 IIC-4 II is a human cervical carcinoma cell line derived from a 41-year-old Caucasian female. These epithelial cells form monolayered colonies with distinct hemicysts, characteristic of transporting epithelia. They exhibit contact inhibition, leading to cell separation and shedding under crowded conditions. Even after extended cultivation, C-4 II cells maintain basal cell differentiation properties and demonstrate G6PD type B. Karyotypic analysis reveals a hypodiploid chromosome number with specific abnormalities, indicating genomic instability. Notably, these cells harbor integrated human papillomavirus type 18 (HPV-18) DNA sequences and actively express HPV-18 RNA. C-4 II cells are tumorigenic, forming poorly differentiated squamous carcinomas when injected subcutaneously into nude mice.

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Citation

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Application

  • The C-4 II cell line  is widely applied across multiple research disciplines. In 3D cell culture, these cells serves as a robust model for investigating cellular behavior and tissue architecture in physiologically relevant 3D environments. In cancer research, C-4 II cells  is instrumental in exploring cervical carcinoma progression and identifying therapeutic targets. Additionally, in infectious disease research, their interaction with human papilloma virus 18 (HPV-18)provides a model to study viral-host interactions and evaluate antiviral approaches. Furthermore, in sexually transmitted disease research, studying HPV-18’s impact on these cells contributes to understanding the virus’s pathogenesis and transmission dynamics, aiding in the development of preventive measures and treatments.

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